Influence of Andrographolide on STZ -induced osmotic and oxidativ | 1804
Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501


Influence of Andrographolide on STZ -induced osmotic and oxidative stress in hepatic tissues of sprague-dawley rats

International Conference on Pharmacognosy, Phytochemistry & Natural Products

October 21-23, 2013 Radisson Blu Plaza Hotel, Hyderabad, India

Ravindar Naik R, Harishanakar N, Praveen Kumar M, Vijaykumar V, Suresh P and Nagaraju T

Accepted Abstracts: Biochem & Pharmacol

Abstract :

Background: Andrographis paniculata (Burm.f.) Nees (Acanthaceae) (AP), containing the major active principle, andrographolide (AG) has been used ethnomedically in the treatment of various diseases. In this context, we have evaluated the effects of Andrographolide on streptozotocin induced oxidative and osmotic stress in Sprague-Dawley rats. Objective: To study the hepatoprotective efficacy of andrographolide on STZ induced diabetic hepatotoxic Sprague Dawley rats. Materials and Methods: Thirty two Sprauge-Dawley rats were taken and maintained under standard experimental conditions and were divided in to four groups, each contain eight rats. Group-I normal control, group-II STZ control and Group-III and IV STZ and treated with AG at 1.5mg, 2.5 mg/kg body weight. The study continued for ?? days and clinical chemistry parameters and oxidative enzyme activities were measured. Gross necropsy and histopathological changes between control and experimental groups were studied. Results and Conclusion: Oral administration of AG reduced the oxidative stress, hepatic marker enzymes towards normalcy in a dose dependent manner. Liver steatosis is significantly reduced in AG treated rats. In conclusion, Andrographolide proved to be effective at both the doses and among the doses, the higher dose proved to be effective in reversing the streptozotocin induced alterations caused by oxidative and osmotic stress and ionic imbalances in the study. Andrographolide acts as potential molecule to treat the hepatic damage. The molecular mechanism behind the hepatoprotective activity of andrographolide is in progress.

Biography :

Ramavat Ravindar Naik Master?s and Doctoral degree obtained from Department of Zoology, Osmania University, Hyderabad. He Joined in National Center for Laboratory Animals, National Institute of Nutrition (Indian Council Of Medical Research) in the year of 2000.He published several articals in reputated National and International journals and also given oral/poster presentations in national and international workshops, conferences, he also having 14 years experience in the field of animal breeding and maintenance. In addition to this he awarded prizes and awards for his work and presentations.