Angiology: Open Access

Angiology: Open Access
Open Access

ISSN: 2329-9495

Antianginal Agents New Findings

Angina results from a reduction in the oxygen supply/demand ratio. Therefore, in order to alleviate the pain, it is necessary to improve this ratio. This can be done either by increasing blood flow (which increases oxygen delivery or supply), or by decreasing oxygen demand (i.e., by decreasing myocardial oxygen consumption).

Pharmacologic interventions that block coronary vasospasm (coronary vasodilators) or inhibit clot formation are used to treat variant and unstable angina, respectively. These drugs act by increasing coronary blood flow and oxygen supply, or by preventing vasospasm and clot formation, and associated decreases in blood flow. Drugs that reduce myocardial oxygen demand are also given to patients with these two forms of angina to reduce oxygen demand and thereby help to alleviate the pain.

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