Two Randomized Cross-Over Trials Assessing the Impact of Dietary Gluten or Wholegrain on the Gut Microbiome and Host Metabolic Health

Sabine Ibrügger¹, Rikke Juul Gøbel², Henrik Vestergaard², Tine Rask Licht³, Hanne Frøkiær⁴, Allan Linneberg^5,6,7, Torben Hansen², Ramneek Gupta⁸, Oluf Pedersen², Mette Kristensen¹ and Lotte Lauritzen^1*

¹Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg C, Denmark, E-mail: ll@life.ku.dk

²The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolics Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, 2100 Copenhagen Ã?, Denmark, E-mail: ll@life.ku.dk

³Division of Food Microbiology, Technical University of Denmark, National Food Institute, Mørkhøj Bygade 19, 2860 Søborg, Denmark, E-mail: ll@life.ku.dk

⁴Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Ridebanevej 9, 1870 Frederiksberg C, Denmark, E-mail: ll@life.ku.dk

⁵Department of Clinical Experimental Research, Glostrup University Hospital, Nordre Ringvej 57, 2600 Glostrup, Denmark, E-mail: ll@life.ku.dk

⁶Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, E-mail: ll@life.ku.dk

⁷Research Centre for Prevention and Health, Glostrup University Hospital, Nordre Ringvej 57, 2600 Glostrup, Denmark, E-mail: ll@life.ku.dk

⁸Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Kemitorvet, 2800 Kgs. Lyngby, Denmark, E-mail: ll@life.ku.dk

^*Corresponding Author: Lotte Lauritzen, Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of Copenhagen, Rolighedsvej 30, 1958 Frederiksberg C, Denmark, Tel: 353 32508, Fax: 353 32483 Email: