The Efficacy of the Kampo Formula Keishikashakuyakuto for Irritable Bowel Syndrome: A Phase 3, Multicenter, Double-Blind, Placebo- Controlled, Randomized Controlled Trial

Takafumi Ito⁵, Atsushi Nakajima^1*, Kunio Kasugai⁸, Yasushi Funaki⁸, Sayuri Yamamoto⁸, Naoki Ohmiya⁷, Yoshihito Nakagawa⁷, Mitsuo Nagasaka⁷, Ken Haruma⁶, Noriaki Manabe⁶, Akira Mizuki⁵, Takuma Higurashi¹, Naoya Okada⁵, Leo Taniguchi⁴, Shungo Goto⁴, Yasuhiko Komiya³, Masataka Taguri², Masahiko Inamori¹, Hiroshi Iida¹, Hidenori Ohkubo¹ and Akiko Fuyuki¹

¹Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan, E-mail: nakajima-tky@umin.ac.jp

²Department of Biostatistics, Yokohama City University School of Medicine, Yokohama, Japan, E-mail: nakajima-tky@umin.ac.jp

³Department of Gastroenterology, Yokosuka General Hospital, Uwamachi, Japan, E-mail: nakajima-tky@umin.ac.jp

⁴Department of Gastroenterology, Hiratsuka City Hospital, Kanagawa, Japan, E-mail: nakajima-tky@umin.ac.jp

⁵Department of Gastroenterology, Keiyu Hospital, Kanagawa, Japan, E-mail: nakajima-tky@umin.ac.jp

⁶Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan, E-mail: nakajima-tky@umin.ac.jp

⁷Department of Gastroenterology, Fujita Health University School of Medicine, Aichi, Japan, E-mail: nakajima-tky@umin.ac.jp

⁸Division of Internat Medicine, Department of Gastroenterology, Aichi Medical University School of Medicine, Aichi, Japan, E-mail: nakajima-tky@umin.ac.jp

^*Corresponding Author: Atsushi Nakajima, Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, 3-9 Fuku-ura, Kanazawaku, Yokohama 236-0004, Japan, Tel: +81-45-787-2640, Fax: +81-45-784-3546 Email: