Success Rate and Possible Causes of Failures of Phase 3 Clinical Trials in Patients with Breast Cancer: A Systematic Review

Mitsugu Ikeda, Tatsuya Ochibe and Masahiro Tohkin^*

Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan, E-mail: ikeda@phar.nagoya-cu.ac.jp

^*Corresponding Author: Masahiro Tohkin, Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan, Tel: +81 52 836 3778 Email:

Keywords: Phase 3 clinical trial; Systematic review; Breast cancer; Primary endpoint; Success rate; Causes of failures; Pre-trial estimate

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