Study Protocol for Prospective Observational Study 1 on the Prognosis of Patients with Unresectable Advanced Gastrointestinal and Pancreatic Neuroendocrine Tumors (PROP-UP 1 Study) in Japan

Mitsuhiro Kida¹³, Tetsuhide Ito^21*, Tatsuo Kagimura²⁰, Masayuki Imamura³, Motohiro Sakamine²⁰, Kazuo Hara¹, Nobumasa Mizuno¹, Shuji Isaji¹⁹, Yoshiaki Tsuchiya¹⁸, Hiroshi Ishii¹⁷, Toshihiko Masui¹⁶, Tomomi Kashiwada¹⁵, Nao Fujimori¹⁴, Kazuhiro Toriyama¹, Yoshitaka Honma¹², Shoji Nakamori¹¹, Hiroaki Yasuda¹⁰, Masanobu Takahashi⁹, Yuichi Tachibana⁸, Masayuki Furukawa⁷, Kentaro Sudo⁶, Yonson Ku⁵, Takuji Okusaka², Noritoshi Kobayashi⁴, Izumi Komoto³ and Susumu Hijioka^1,2

¹Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

²Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

³Department of Surgery and NEN Center, Kansai Electric Power Hospital, Osaka, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

⁴Department of Oncology, Yokohama City University, Graduate School of Medicine, Yokohama, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

⁵Department of Hepato-Biliary-Pancreatic Surgery, Kobe University, Graduate School of Medicine, Kobe, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

⁶Department of Gastroenterology, Chiba Cancer Center, Chiba, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

⁷Department of Hepato-Biliary-Pancreatology, National Kyushu Cancer Center, Fukuoka, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

⁸Department of Medicine and Bioregulatory Science, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

⁹Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹⁰Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹¹Department of Hepato-Biliary-Pancreatic Surgery, Osaka National Hospital, Osaka, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹²Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹³Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹⁴Department of Hepatology and Pancreatology, Kyushu University Hospital, Fukuoka, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹⁵Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Saga University, Faculty of Medicine, Saga, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹⁶Department of Hepato-Biliary-Pancreatic Surgery and Transplantation, Kyoto University, Kyoto, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹⁷Department of Gastroenterology, Shikoku Cancer Center Hospital, Matsuyama, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹⁸Department of Surgery, Niigata Cancer Center Hospital, Niigata, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

¹⁹Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

²⁰Foundation for Biomedical Research and Innovation at Kobe, Translational Research Center for Medical Innovation, Kobe, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

²¹Department of Hepato-Biliary-Pancreatic Medicine and Neuroendocrine Tumor Centre, International University of Health and Welfare and Fukuoka Sanno Hospital, Fukuoka, Japan, E-mail: toriyama@med.nagoya-cu.ac.jp

^*Corresponding Author: Tetsuhide Ito, Department of Hepato-Biliary-Pancreatic Medicine and Neuroendocrine Tumor Centre, Fukuoka Sanno Hospital and International University of Health and Welfare, Fukuoka, Japan, Tel: +81-92-832-1100, Fax: +81-92-832-1102 Email:

Keywords: Observational study; Gastroenteropancreatic neuroendocrine neoplasm; Japan

Introduction