Signaling Mechanisms that Balance Anti-viral, Auto-reactive, and Antitumor Potential of Low Affinity T Cells

Michael Hebeisen^1,2, Nathalie Rufer^1,2, Susanne G. Oberle³, Daniel E Speiser² and Dietmar Zehn^3*

¹Department of Research, Lausanne University Hospital Center and University of Lausanne, Lausanne, Switzerland

²Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland

³Swiss Vaccine Research Institute (SVRI), 1066 Epalinges, Switzerland; and Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland

^*Corresponding Author: Dietmar Zehn, Swiss Vaccine Research Institute Centre des laboratoires d’Epalinges–CLE, Ch. Des Boveresses 155 1066 Epalinges, Switzerland, Tel: +41(21)6925912, Fax: +41(21)3141070 Email: