Rhodiola Rosea Therapy for Major Depressive Disorder: A Study Protocol for a Randomized, Double-Blind, Placebo- Controlled Trial

Jun J Mao^1,2,3*, Qing S Li¹, Irene Soeller¹, Sharon X Xie² and Jay D Amsterdam⁴

¹Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA, E-mail: jun.mao@uphs.upenn.edu

²Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA, E-mail: jun.mao@uphs.upenn.edu

³Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA, E-mail: jun.mao@uphs.upenn.edu

⁴Depression Research Unit, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA, E-mail: jun.mao@uphs.upenn.edu

^*Corresponding Author: Jun J Mao, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania, 227 Blockley Hall, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA, Tel: 215-746-2481, Fax: 215-662-3591 Email: