Journal of Clinical and Experimental Ophthalmology

Journal of Clinical and Experimental Ophthalmology
Open Access

ISSN: 2155-9570

Perspective - (2025)Volume 16, Issue 1

Retinoblastoma: Understanding Childhood Eye Cancer

Carol Shields*
 
*Correspondence: Carol Shields, Department of Ophthalmology, Sun Yat-Sen University, Guangzhou, China, Email:

Author info »

Description

Retinoblastoma is a rare but serious form of eye cancer that primarily affects children, most commonly under the age of five. It originates in the retina, the light-sensitive layer of tissue at the back of the eye, and can occur in one or both eyes. Although retinoblastoma is relatively rare, it is one of the most common cancers of the eye in young children, and its early detection and treatment are vital to preventing vision loss and potentially saving a child's life. 

In this article, we will explore retinoblastoma in detail, covering its causes, symptoms, diagnosis, treatment options, and the longterm impact of the disease. By understanding the disease better, we can improve early detection, support families facing retinoblastoma, and promote ongoing research into more effective treatments. 

Retinoblastoma is a type of cancer that starts in the retina, the light-sensitive tissue at the back of the eye that plays a critical role in vision. In this cancer, a group of abnormal cells in the retina begin to grow uncontrollably, forming a tumor. This can lead to vision impairment, and if left untreated, it may spread to other parts of the body. 

Retinoblastoma can develop in one eye (unilateral) or both eyes (bilateral). When the cancer affects both eyes, it is typically diagnosed at an earlier age, often before the child turns two.

Treatment of retinoblastoma

The treatment of retinoblastoma depends on the size and location of the tumor, whether one or both eyes are involved, and whether the cancer has spread beyond the eye. The main goals of treatment are to remove the tumor, preserve vision if possible, and prevent the cancer from spreading.

Enucleation (surgical removal of the eye): In cases where the tumor is large, affects the entire eye, or cannot be treated with other methods, enucleation may be necessary. This involves the removal of the affected eye to prevent the spread of cancer. After enucleation, children may be fitted with a prosthetic eye.

Chemotherapy: It is commonly used for retinoblastoma, particularly in cases where the cancer is bilateral or has spread beyond the eye. Chemotherapy drugs are given intravenously to target and kill rapidly dividing cancer cells. It can be used before surgery (neoadjuvant chemotherapy) to shrink the tumor or after surgery to eliminate any remaining cancer cells.

• In some cases, chemotherapy may be delivered directly to the eye (intra-arterial chemotherapy) to target the tumor more specifically. 

Laser therapy and cryotherapy: For smaller tumors or tumors located at the peripheral edges of the retina, laser therapy or cryotherapy may be used. These treatments work by destroying the tumor cells using extreme cold (cryotherapy) or intense light (laser therapy). 

Radiation therapy: In some cases, radiation therapy may be used to shrink the tumor or to treat any remaining cancer cells after surgery. Proton beam radiation is commonly used in retinoblastoma because it delivers precise doses of radiation while minimizing damage to surrounding tissues. 

Thermal therapy: In some advanced cases, a technique called thermotherapy may be employed, which uses heat to destroy cancer cells. 

Gene therapy: Though still experimental, gene therapy may offer future potential for treating retinoblastoma by correcting mutations in the RB1 gene or introducing new genetic material to help the body fight the cancer.

Conclusion

Retinoblastoma is a rare but treatable form of childhood eye cancer. Early detection, effective treatments, and a multidisciplinary approach to care have significantly improved the prognosis for children with retinoblastoma. With ongoing research into more targeted therapies, genetic advancements, and the development of less invasive treatments, the future for children diagnosed with retinoblastoma looks increasingly optimistic. However, it remains important for parents and healthcare providers to be vigilant about the early signs and symptoms of this disease to ensure the best possible outcome for affected children.

Author Info

Carol Shields*
 
Department of Ophthalmology, Sun Yat-Sen University, Guangzhou, China
 

Citation: Shields C (2025). Retinoblastoma: Understanding Childhood Eye Cancer. Clin Exp Ophthalmol. 16:998

Received: 01-Dec-2025, Manuscript No. JCEO-25-371668; Editor assigned: 03-Jan-2025, Pre QC No. JCEO-25-371668 (PQ); Reviewed: 17-Jan-2025, QC No. JCEO-25-371668; Revised: 24-Jan-2025, Manuscript No. JCEO-25-371668 (R); Published: 31-Jan-2025 , DOI: 10.35248/2155-9570.25.16.998

Copyright: © 2025 Shields C. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited

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