Prevention of Relapse and Recurrence of Bipolar Type I Depression: A Study Protocol for a Multi-site Randomized, Double-blind, Placebo-substitution Trial

Jay D Amsterdam^1*, John Zajecka², Irene Soeller^1,3, Michael Topel², Corey Goldstein² and Robert J DeRubeis⁴

¹Depression Research Unit, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA, E-mail: jamsterd@mail.med.upenn.edu

²Department of Psychiatry, Treatment Research Center, Rush Medical Center, Chicago, IL, USA, E-mail: jamsterd@mail.med.upenn.edu

³Department of Family Medicine and Community Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA, E-mail: jamsterd@mail.med.upenn.edu

⁴Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA, E-mail: jamsterd@mail.med.upenn.edu

^*Corresponding Author: Jay D Amsterdam, Depression research unit, 3535 Market Street (3rd floor), Philadelphia, PA 19104, USA, Fax: 215-662-6443 Email: