Phase II Trial of Neoadjuvant Chemotherapy using Triplet without Radiotherapy for Borderline Resectable Advanced Rectal Cancer in Japan (NEUTRAL Trial)

Kinuko Nagayoshi¹, Shuntaro Nagai¹, Yoshihiko Sadakari¹, Hayato Fujita¹, Kenji Tsuchihashi², Tatsuya Manabe³, Yoshitaka Tanabe⁴, Takashi Ueki⁵, Eishi Baba⁶ and Masafumi Nakamura^1*

¹Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

²Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

³Department of Surgery, Faculty of Medicine, Saga University, Saga, Japan

⁴Department of Surgery, Kitakyushu Municipal Medical Center, Fukuoka, Japan

⁵Department of Surgery, Hamanomachi Hospital, Kitakyushu, Japan

⁶Department of Comprehensive Clinical Oncology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan

^*Corresponding Author: Masafumi Nakamura, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Tel: +81-92-642-5441, Fax: +81-92-642-5458 Email:

Keywords: Chemotherapy; Radiotherapy; Rectal Cancer

Introduction