Parallel Pilot Trials of Screening Frequency for Liberation from Mechanical Ventilation the RELEASE Trial and SENIOR Trial Protocols

Jan O. Friedrich^1,2,3, Maureen O Meade⁴, Kevin Thorpe^3,13, Julia Lee RRT², Fatma Rajwani², Christine Leger², Eddy Fan^1,12, Laurent Brochard^1,2,3, Andrew J Seely¹¹, Karen EA Burns^1,2,3*, Francois Lamontagne¹⁰, Michelle E Kho PT⁹, Sangeeta Mehta^2,3,8, Peter Dodek^6,7, Deborah J Cook^4,5, Lori Hand⁴, Leena Rizvi² and Jessica TY Wong²

¹Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada

²Division of Critical Care Medicine, St Michael’s Hospital, Toronto, Canada

³Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Canada

⁴CLARITY, McMaster University, Hamilton, Canada

⁵St Joseph’s Hospital, Hamilton, Canada

⁶Centre for Health Evaluation and Outcome Sciences and Division of Critical Care Medicine, St Paul’s Hospital, Canada

⁷University of British Columbia, Vancouver, Canada

⁸Mount Sinai Hospital, Toronto, Canada

⁹School of Rehab Science, McMaster University, Hamilton, Canada

¹⁰Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada

¹¹Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada

¹²University Health Network, University Health Network, Toronto, Canada

¹³Dalla Lana School of Public Health, Institute of Health Policy Management and Evaluation, Toronto, Canada

^*Corresponding Author: Karen EA Burns, Clinician Scientist, Division of Critical Care, Department of Medicine, St. Michael’s Hospital and the Li Ka Shing Knowledge Institute, 30 Bond Street, Office 4-045 Donnelly Wing Toronto, ONT, Canada, Tel: 416-864-6060 X3567 Email: