Impaired Signaling Intrinsic to Sinoatrial Node Pacemaker Cells Affects Heart Rate Variability during Cardiac Disease

Yael Yaniv^1*, Alexey E Lyashkov² and Edward G Lakatta¹

¹Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA, E-mail: yanivyael@gmail.com

²Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, Maryland, USA, E-mail: yanivyael@gmail.com

^*Corresponding Author: Yael Yaniv, Laboratory of Cardiovascular Science, Biomedical Research Center, Intramural Research, Program, National Institute on Aging, NIH, Baltimore, Maryland, USA, Tel: 410-558-8093 Email: