Immunological Signatures Identifying Different Stages of Latent Mycobacterium tuberculosis Infection and Discriminating Latent from Active Tuberculosis in Humans

Kaatje Smits¹, Véronique Corbière¹, Violette Dirix¹, Leila Mekkaoui¹, Chloé Wyndham-Thomas¹, Myriam Libin¹, Alexandra Dreesman¹, Marc Loyens^2,3,4,5, Marie-Christine Payen⁶, Mahavir Singh⁷, Camille Locht^2,3,4,5 and Françoise Mascart^1,8*

¹Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium

²INSERM U 1019, Lille, France

³CNRS, UMR8204, Lille, France

⁴Université de Lille, Lille, France

⁵Institut Pasteur de Lille, Centre d’Infection et d’Immunité de Lille, Lille, France

⁶Department of Infectious Diseases, CHU Saint-Pierre, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium

⁷Lionex, Braunschweig, Germany

⁸Immunobiology Clinic, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium

^*Corresponding Author: Françoise Mascart, Immunobiology Clinic, Hôpital Erasme, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium, Tel: 322-555-3467, Fax: 322-555-4499 Email: