Design of a Multicenter, Randomized, Open Label, Parallel Group Study to Evaluate the Efficacy of Loxoprofen on Acute-Phase Reactions in Japanese Primary Osteoporosis Patients Treated with Zoledronic Acid

Nobukazu Okimoto^1*, Akinori Sakai², Hidehiro Matsumoto³, Satoshi Ikeda⁴, Kunitaka Menuki², Toru Yoshioka⁵, Tomohiro Kobayashi⁵, Toru Ishikura⁶ and Saeko Fujiwara⁷

¹Okimoto Clinic, 185-4 Kubi, Yutakamachi, Kure-shi, Hiroshima 734-0304, Japan, E-mail: noboki4@yahoo.co.jp

²Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan, E-mail: noboki4@yahoo.co.jp

³Department of Orthopaedic Surgery, Sanzai Hospital, Miyazaki, Japan, E-mail: noboki4@yahoo.co.jp

⁴Department of Orthopaedic Surgery, Ken-Ai Memorial Hospital, Fukuoka, Japan, E-mail: noboki4@yahoo.co.jp

⁵Department of Orthopaedic Surgery, Shimura Hospital, Hiroshima, Japan, E-mail: noboki4@yahoo.co.jp

⁶Department of Orthopaedics, Youmeikai Obase Hospital, Fukuoka, Japan, E-mail: noboki4@yahoo.co.jp

⁷Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan, E-mail: noboki4@yahoo.co.jp

^*Corresponding Author: Nobukazu Okimoto, Okimoto Clinic, 185-4 Kubi, Yutakamachi, Kure-shi, Hiroshima 734-0304, Japan, Tel: +81-823-66-2314, Fax: +81-823-66-2334 Email: