Brainstem Sparing in Human Prion Disease: Sleep and Autonomic Function in a Long Survival Case Report

Alessandro Pincherle^1,2*, Eleonora Tobaldini³, Lucio Mos³, Ambra Dominese², Vincenzo Patruno⁴, Nicola Montano³, Flavio Villani², Fabrizio Tagliavini², Giorgio Giaccone² and Gabriella Marcon^2,3,4,5,6

¹Neurology Unit, Spitalzentrum Biel, Biel, Switzerland

²Fondazione IRCCS Istituto Neurologico “Carlo Besta”, Milan, Italy

³Department of Biomedical and Clinical Sciences “L. Sacco”, Medicine and Physiopathology Unit, L. Sacco Hospital, University of Milan, Italy

⁴Department of Cardiology, San Daniele del Friuli Hospital, Udine, Italy

⁵Pneumologia Riabilitativa, Istituto di Medicina Fisica e Riabilitazione “Gervasutta”, Udine, Italy

⁶Department of Biological and Medical Sciences (DSMB), University of Udine, Italy

^*Corresponding Author: Alessandro Pincherle, Neurology Unit, Spitalzentrum Biel, Biel, Switzerland, Tel: 0041323444763 Email: