ISSN: 2161-0533
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Review Article - (2019) Volume 8, Issue 1
Received Date: Dec 07, 2018 / Accepted Date: Jan 02, 2019 / Published Date: Jan 09, 2019
Bertolotti’s Syndrome (BS) or Lumbosacral Transitional Vertebra (LSTV) is the most common congenital malformation of the lumbosacral junction. It encompasses from sacralization of L5 to lumbarization of S1. The prevalence ranges from 5% to 15% in different population base. Adolescents and middle-aged people are commonly affected. Clinical spectrum can range from asymptomatic individual to a constant low Backache (LBA) with or without radicular pain in buttocks or legs. Currently, there is no consensus about its association with low back pain and its subsequent management. We thoroughly evaluated all prominent literature regarding its diagnostic methods, classification, and subsequent management.
Keywords: Bertolottiâs syndrome; Lumbosacral transitional vertebra; Sacralisation; Lumbarisation
Bertolotti’s syndrome or lumbosacral transitional vertebra syndrome is a common cause of lower back pain, especially in the younger population. Since its identification by bertolotti in 1917, it has been a constant topic of debate regarding its association with a low backache and its subsequent management [1]. Being the most common congenital abnormality of the LS junction, symptomatology extends from asymptomatic incidental finding to a constant source of a low backache in adolescent to middle-aged population. Morphological changes in the L5 and/or S1 vertebrae lead to abnormal biomechanics and kinematics at LS junction that results in decrease motion at the involved parts with consequently increased mobility and stress at an adjacent segment of the spine. The problem ranges from the enlarged transverse process of a fifth lumbar vertebra, pseudo-arthrosis between the enlarged transverse process and sacral ala and/or ilium, and complete fusion, to lumbarization of the first sacral vertebral body. As it involves a younger population, a constant LBA can cause psychosocial frustration, work inefficiency and loss of productive and economic activity. Presently, there is no consensus regarding its diagnostic methods and subsequent management.
In Lumbosacral Transitional Vertebra Syndrome (LSTV) either the last lumbar vertebra (L5) acquires varying degrees of articulation to the sacrum and/or to the ilium (sacralization) or the first sacral segment (S1) is separated from the sacrum with the transition to a lumbar configuration (lumbarization). A sacralization is a congenital anomalous enlargement of transverse processes of the most caudal lumbar vertebra with subsequent neo-articulation or fusion to the sacrum. Mario Bertolotti1 in 1917 first identified and termed it as bertolotti’s syndrome. He stated that LSTV might cause low back pain due to arthritic changes at the pseudo-arthrosis site. Further, radiographically classified it into four types [2] (Figure 1). A type first comprises unilateral (Ia) or bilateral (Ib) dysplastic transverse processes, measuring at least 19mm of height in the vertical dimension. A type 2 involves unilateral (IIa, Figure 2) or bilateral (IIb) lumbarization/sacralization with the formation of a diarthrodial joint between the overgrown transverse process and sacral ala. A type 3 exhibits unilateral (IIIa) or bilateral (IIIb, Figures 3 and 4) fusion of enlarged transverse processes to sacral ala and/or ilium. Type IV involves a unilateral type II transition with a type III on the contralateral side. O’ Driscoll et al., [3] classified lumbosacral junction into four types based on MRI finding.
On correlation with plane radiographs, it was found that 12 patients with type IV MRI appearance had radio-graphical similarities with either Castellvi type II or III. However, it was not confirmed whether the intervertebral disc concerned was between a lumbarizied S1 and S2 or between sacralized L5 and S1 (Table 1).
Types | Status of first sacral intervertebral disc |
---|---|
1 | No disc material present between S1 and the remainder of the sacrum, the junction being identified by a low signal line |
2 | A small residual disc between S1 and the remainder of the sacrum, with the antero-posterior (AP) diameter of the disc being less than the AP diameter of the sacrum |
3 | A well-formed residual disc between S1 and the remainder of the sacrum, the AP diameter of the disc equalling the AP diameter of the sacrum |
4 | A well-formed residual disc between S1 and the remainder of the sacrum but also with an abnormal sagittal outline to the sacrum, i.e. ‘‘squaring’’ of the presumed upper sacral segment |
Table 1: Classification of lumbosacral disc morphology. [3]
A cadaver study theorized that congenitally small sacral surface area tries to add more surfaces by the body’s compensatory mechanism and functional requirement. Consequently, it involves L5 transverse processes in the neo-articulation and its subsequent fusion to sacral ala. Conversely, in case of large sacral surface area, the articulation leaves S1 from sacroiliac articulation and as a result, S1 lumbarization occurs [4].
Apart from transverse process changes and neo-articulation (sacralization), morphological changes also affect other parts of the vertebra affected. In sacralization, pedal height, its transverse and sagittal dimension, and saggital angulation are decreased and caudal angulation increased. The width of laminae and height of pars interarticularis (PI) decrease. A smaller PI renders the spine vulnerable to spondylolysis and spondylolisthesis [5]. Lumbarization of the S1 conversely results in obtuse pedicles, the short distance between facets and sacral promontory [6]. The transitional vertebra shows facets joint changes. In lumbarization, facet linear dimension and surface area are decreased and with maximal coronal orientation. Sacralisation does not show much changes in morphology [7]. Nicholson et al., observed a radiographically decreased intervertebral disc height between the lumbar transitional segment and the sacrum in comparison to a normal disc between L5 and S1 [8]. Conversely, in the case of lumbarization of S1, the S1-S2 disc assumes larger height, contrary to the normal disc, which is rudimentary and vestigial one.
There is always an ambiguity regarding which nerve is which in the scenario of LSTV because of altered anatomy. McCulloch and Waddle et al., stated that functional L5 root always originates from the last mobile segment of the spine [9]. The last mobile segment is defined as the vertebra, which has fully formed disc with bilaterally welldeveloped faced joints and separate transverse processes. Therefore, in sacralized L5, the functional L5 correspond to the anatomical L4 nerve root. In lumbarized S1, L5 nerve root corresponds to the S1 nerve root.
Prevalence of LSTV is varied in the literature due to differences in definition and diagnostic modalities employed. It ranges from 4% to 35.9% with a mean of 12.3% [10-12]. Apazidis et al., reported LSTV Castellvi type Ia as the most common occurrence with a prevalence rate of 14.7%, though type Ia is considered of low clinical significance [13]. Nardo et al. reported that 40% of his cases of LSTV were of Castelvi type I and II [12]. Type III and type IV accounted for 11.5% and 5.25% respectively.
LSTV was reported more in men than women. A sacralization is more common in men, while lumbarization of S1 is more prevalent in women [12,14]. Common findings in some families suggested some genetic association responsible for the segmental development of the lumbosacral spine [11]. Embryonic development and segmentation of spine is probably controlled by families of genes, termed homeobox genes. These are abbreviated to Hox in mice and HOX in humans and are found on four clusters known as A, B, C, and D. Individual genes are numbered from 1 to 13. 1 is a cephalic gene and 13 is a more caudally placed gene [15].
Due to dysplastic changes in vertebrae and intervertebral disc space, it is not always easy to identify and number the vertebrae in the lumbosacral area. A Full x-ray of the whole spine or a CT scan is seldom done. Nonetheless, a standard anteroposterior and lateral radiograph of the lumbosacral spine can help reveal the transitional vertebra. Normally, most caudal rectangular or square shaped vertebra is considered as L5 in a lateral radiograph. In an LSTV, the last rectangular shape can coincide with either L4 or L6/S1, depending upon whether it is a sacralization or a lumbarisation. A transformation of S1 into lumbar configuration can be identified when it assumes a square shape from a rhombus or wedge shape, described as “squaring”. The ratio of AP distance of superior end-plate and the inferior endplate in lateral radiograph decreases and it is less than or equal to 1.37 [16]. The involved transitional vertebral body of S1 appears squared up. The normal acute angulation between L5 and S1 is reduced and lumbar lordosis is found to be exaggerated. Conversely, a sacralized L5 may depict the picture similar to S1 and transforms into a rhombus and wedge-shaped and the infrajacent disc space appears decreased in height and a vestigial one [17,18].
An anteroposterior radiograph with the beam directed 300 cephalad (Ferguson view) and coronal sections of CT scan reveal an array of information from a broadened and enlarged Transverse Processes (TP) of L5, a pseudo-articulation at TP and sacral ala and ilium to complete fusion. Axial cuts of CT scan highlight a neo-articulation, facet joint orientation and their spatial relationship. 3D NC-CT also allows seeing morphological changes in the transitional vertebra. A standard radiograph can fairly diagnose all types of LSTV with accuracy ranging from 53% to 58%.
The numbering of a vertebra in association with BS is also important as it has a great bearing on the localization of the level in the planning of surgery. Without definite identification and numbering, a wrong level surgery may ensue. For that purpose, a preoperative identification and numbering with correlation with intraoperative images are desired. Many times only a radiograph or MRI of the lumbosacral region is available. What appears as L1 with the transverse process in AP radiograph, in essence, maybe a T12 vertebra with hypoplastic ribs. Similarly, Hughes RJ et al. described the identification of iliolumbar ligament in MRI sections for the numbering purpose as it reliably arises from L5 transverse processes (TP) [19]. It originates from L5 TP and extends to the posteromedial iliac crest. It is visible as low signal images in both T1 and T2 weighted axial images. Hughes et al., labeled an LSTV as L5 when no iliolumbar ligament was identified at the level above. When an iliolumbar ligament was seen to arise above the LSTV, then the vertebral body with iliolumbar ligament was labeled L5 and the LSTV as S1 [19]. However, this technique assumes that there are always 7 cervicals, 12 thoracic and 5 lumbar vertebrae. It also does not respect the possibility of various segmentation anomalies at the thoracolumbar junction. A radiograph of the whole spine with the use of MR localizer helps in counting the vertebrae inferiorly from C2 and may help in true numbering [20]. However, MR sagittal images sometime may not pick up the changes. Tokgoz et al. did a large study in 1049 patients using MRI of the lumbosacral area with a whole spine localizer and reported that about 1.3% patients were wrongly diagnosed as having LSTV, while 35.1% patients of abnormal segmentation were wrongly labeled as having normal segmentation [21]. Even after correctly identifying LSTV, they reported incorrect vertebral level numbering in 60% of cases with a total diagnostic error in 14.1% cases. Lumbarization of S1 demonstrated a well-formed IVD at S1-S2 level with squared up S1 body. Sacralization revealed a rhombus-shaped L5 body.
Some anatomic landmarks such as a right renal artery, aortic bifurcation, and level of connus medullaris have also been studied. Lee et al., stated that aortic bifurcation and right renal artery are reliable landmarks in MRI or CT for identification of lumbosacral segments [17]. Most of the times, right renal artery is present at L1-L2 disc level, but it is not always imaged or present in other locations in approximately 25% of cases [22].
Farshad et al., described a novel method of identifying an LSTV [23]. The difference in the vertical mid-vertebral angles (Diff-VMVA) and the difference in the vertical anterior vertebral angles (Diff- VAVA) of the last three caudal segment of the spine were calculated in sagittal MRI and lateral radiograph. A Diff-VMVA of <100 identified type III and type IV LSTV with a sensitivity of 100% and a specificity of 89% on MRI and a sensitivity of 94% and a specificity of 74% on the lateral radiograph. Also, a Diff-VAVA, a sensitivity of 100% and a specificity of 76% were obtained.
Paik et al., suggested the inclusion of the cervical spine in MR Imaging for numerically counting of the vertebrae to identify LSTV. In their study, 89.2% had 5 lumbar vertebrae (L5), 2.6% had 4 lumbar vertebrae (L4) and 8.2% had 6 lumbar vertebrae (L6) [11]. Types II, III, or IV LSTV were present in 10.6% of the patients, including 5.3% of sacralized L5 and 5.3% of lumbarized S1. Only 83.9% of patients were the modal type with 5 lumbar vertebrae without transitional vertebra. The last lumbar vertebra with no transition, looking like a modal L5 type, can be an L4 or an L6, as seen in 2.6% and 2.9% of the patients, respectively.
The exiting spinal nerves may get pinched because of bony growth. Weber et al. reported two cases of LSTV resulting in entrapment of L5 nerve root between enlarge transverse process and sacral ala with osteophytes and bone spur formation [15] (Figures 5 and 6). Excision of the abnormal growth and bony osteophytes resulted in successful relieving of radicular pain and dysesthesia in the L5 nerve distribution. Unilateral or bilateral dysplastic facet joints were also found just below the transitional vertebra.
Radiographical presence of degeneration at the new articulation and intervertebral joints in LSTV may not correlate with patient’s symptomatology. To find out the painful focus, the metabolic activity of the region was also studied widely by using planar and SPECT bone scintigraphy to find an inflammatory focus. Pekindil G et al., demonstrated non-focal mild uptake in eight asymptomatic LSTV cases [24]. Symptomatic LSTV without degeneration patients showed nonfocal mild uptake; whereas symptomatic LSTV patients with radiographically noted degenerative spine revealed focal, marked uptake on SPECT bone scintigraphy. It is the degenerative spine at the pseudo-articulation site and facet joints, which cast an increased uptake. Although, Jonsson et al., reported normal planar bone scan findings in eight patients with unilateral LSTV articulation [25]. In author’s view, though a single modality may not diagnose the problem, yet a combination of investigations such as plane radiograph, CT scan, and MR localizer can fairly diagnose and classify all the variants of lumbosacral transitional vertebrae.
The transitional vertebra in lumbosacral region disturbs normal biomechanical anatomy. The sacrum, a large triangular bone, dissipates and transmits body weight to the limb through SI joints. This capability of it surely depends on the surface area of the articulation. Pathophysiology of pain generation in presence of LSTV has always been unclear. Many studies found an increased prevalence of degenerative process at superjacent disc level to LSTV [2,26]. Causes of low back pain in association with transitional vertebra are multifactorial in origin. Presence of extra-foraminal stenosis, spinal stenosis; nerve root canal stenosis and facet joint degeneration were some of the proposed mechanisms for low back pain with or without radicular pain [27,28]. Connolly et al., studied skeletal scintigraphy in young patients with LSTV and demonstrated that mechanical stress at the pseudo-articulation could cause low back pain [29].
Even after identification of transitional vertebra, there are many controversies regarding its association and mechanism of LBA. An increase in the prevalence of disc degeneration and a protrusion or extrusion is found in the disc above the transitional L5 vertebra [2,9,30,31]. It has been found and theorized that an LSTV causing reduced mobility at L5-S1 leads to hypo-mobility at that level. Consequently, hypermobility and stress are generated at L4-L5, which cause disc degeneration, protrusion/extrusion, and early facet joint degeneration. In contrast, the Inter-vertebral disc at the transitional zone is protected (Figure 7) [16,30,31]. Asymmetric transitional vertebra has been considered as a potential source of low back pain [29]. Presence of sclerotic changes and bony osteophytes signify that a slight amount of motion may occur at pseudo-articulation site, resulting in LBA [32].
Nardo et al. proposed that there is a positive relationship between LSTV type II and type IV and LBA [12]. Quinlan et al., also concluded that LSTV should be considered as a possible cause of LBA [33]. Wiltse, pointed out that the bony enlargement of the L5 transverse process can lead to nerve entrapment between the anomaly and sacral ala and named it “far out syndrome” [34].
Conversely, several studies also found contradictory results [35] Luoma et al., in an MRI study of asymptomatic patients found that though there was an increased prevalence of degeneration of the disc above the LSTV, an association between the findings and LBA was lacking [10]. Tiny et al., included 4000 patients and did not report that LSTV was associated with LBA [36].
Treatment of lumbosacral transitional vertebra has been controversial as some studies refuted its association with a low backache [14,16]. In contrast, some authors also indicated its relationship with increased lumbar degenerative disc disease at the suprajacent level and pain generation at the false joint between the L5 transverse process and sacral ala [12,33]. Presence of transition vertebra and concurrent back pain pause a great diagnostic and treatment decision-making problem to the clinicians. Several authors indicated that LSTV, particularly castellvi type II and type IV potentially could be a source of low back pain [12] and should always be considered in differential diagnoses of low back pain in the younger population. Reduced mobility at the L5S1 level and consequently, increased abnormal and asymmetric stress can result in early degenerative changes within the “neo-articulation” or in the normal contralateral facet joint.
As far as management is concerned, it begins with conservative management, as is the case with patients of LBA without LSTV. There are several small studies and case reports about successful initial management of the patients using therapeutic mobilization and physical therapy [37] although, literature evidenced BS patients do benefit poorly if physiotherapy is used alone or in combination with anti-inflammatory and analgesic agents.
Considering the multifactorial origin site of pain, it is quite difficult to pinpoint the pain generators using a radiograph and/or an MRI alone. Injection of local anesthetic agents in the potential site of pain is a fairly good approach to pinpoint all the areas, which are problematic. In addition, bone scan or SPECT/CT scintigraphy may potentially suggest the culprit areas. Anuj et al. used a block method to locate the pain generators in BS caltelvi type IA [38]. In their study, after confirmation of pain site using blocks, radio-frequency ablation of the rami communicants, SI joint RF, DRG pRF and nucleoplasm were used as a definitive treatment with relief extended beyond 6 months. Out of them, neo-articulation was the worst in terms of pain relief. A sacroilitis also fared poorly with radiofrequency denervation.
Relief from local anesthetic and steroid injection at neo-articulation site has been variable with no consistent results. Robert C Mark et al., prospectively followed a cohort of 10 patients with severe LBA diagnosed with an LSTV on X-ray [39]. All patients received X-ray guided injection of steroids and local anesthetic agent. Out of them, 8 patients had immediate pain relief and 1 patient had total pain relief after one week of injection. 5 of them had a recurrence of pain ranging from 1 day to 12 weeks of injection. Three patients reported partial pain relief lasting from 7 to 41 months and 1 patient was pain-free till 2 years after the injection.
Avimadje et al., [40] retrospectively studied 12 patients with LSTV with same side LBA and buttock pain. 11 patients received steroid injection at pseudo articulation site. Out of them 9 patients reported 50% pain relief at 1 month follow up. One patient lost to follow up. 7 out of 8 patients had improved or had no pain at 6 to 24 months later 2 patients received 2nd injection at one and two months respectively, after the first injection. They emphasized that results of local steroid injection are also unpredictable, but still it should be considered in patients with LSTV before considering for surgical means of treatment.
There is a paucity of literature regarding surgical treatment of LBA in association with bertolotti’s syndrome. Santavirta et al. treated 16 patients of bertolotti’s syndrome aged 27 to 58 years (mean-34) with operative treatment [41]. Surgical methods included posterolateral fusion in half of the patients and surgical resection of enlarged transverse process in the other half. He observed that though pain intensity in the postoperative group was improved, it was only slightly better than the conservatively treated group. He emphasized that operative treatment should be considered in those patients who have exhausted the conservative treatment. Prior to surgical execution, disc pathology just above and below the transitional vertebra should be considered. Surgical resection of the transverse process should be considered when the pain truly arises from the neo-articulation site. Conversely, posterolateral fusion may be offered to those who have disc pathology in term of degeneration, protrusion etc. at infradjacent disc level.
Jonsson et al., anesthetized the neo-articulation first and observed considerable improvement in the majority of his patients, even-though bone scintimetry using 99m Tc MDP had not shown an increased uptake in most of the patients [25]. Out of 11 patients (mean follow up of 17 months), 9 patients reported long-lasting significant to complete alleviation of symptoms after surgical resection of the enlarged TP. It can be inferred that not all the neo-articulation site and subsequent degeneration their-of are painful and as a result, they may show a cold spot on bone scintigraphy. They postulated that it is the hypermobility rectification between the rostral lumbar segment and sacrum, which relieved the LBA following resection of neo-articulation.
Pain arising from the facet joint contra-lateral to the pseudo joint also has been claimed. Jeffrey S et al., treated one case of BS by prior confirmation with an injection of anesthetic agents and subsequent excision of neo-articulation site and had successful pain relief at the contralateral facet site at one-year follow-up [42].
The minimally invasive technique has also been employed to resect the overgrown transverse process of L5 and reported to having good pain relief in short term follow-up [43]. Li et al. treated 7 patients of BS using minimally invasive tubular resection of overgrown L5 TP [44]. 3 out of 7 patients reported complete relief in symptoms, 2 out of 7 reported reduced pain intensity and 2 of 7 reported initial pain relief but recurrence of pain at 1 and 4 years of surgery was observed.
Almeida et al., treated 5 patients of BS with prior infiltration of neoarticulation with the anesthetic agent [45]. 3 out of 5 got partial relief and 2 out of 5 had significant relief. The later were subjected to surgical resection of transverse mega-apophysis and got total pain relief in the long run. He theorized the principle of low back pain care in presence of bertolotti’s syndrome. General norm of a low backache with BS starts from conservative management in form of NSAIDS, physiotherapy and chiropractic manipulations. Those who do not respond to this regime are a potential candidate for diagnostic and sometimes therapeutic injection of steroid and anesthetic agents at neo-articulation site or the contralateral facet joint, although, no previous studies reported any prognostic value of this procedure. Candidates, who have had partial/significant pain relief from the injection, may be enrolled for surgical resection of the overgrown L5 transverse process. In association with significant degeneration of contralateral facet joint, a fusion procedure at L5 and S1 in form of TLIF/PLIF is a better choice.
Chang il ju et al., studied 256 patients of bertolotti’s syndrome and chose to give steroid injections at pseudo-articulation in 87 cases [22]. 26 cases were excluded from study analysis because of the elimination of confounding factors like the presence of other spinal diseases viz. spinal stenosis, disc herniation, and spondylolisthesis. Group A (39 cases) received local steroid and anesthetic agent injection at pseudoarticulation site and the group B (22 cases) received selective L4 nerve root block. After confirming temporary relief, all 61 patients were subjected to L5 transverse proctectomy. In group A, preoperative VAS score was 7.59 ± 0.93 and postoperative VAS score was 3.82 ± 1.59. In group B, pre-surgical average VAS score was 7.50 ± 0.86 and postsurgical VAS score was 2.05 ± 1. Average follow up duration was 10 months. In their study, effective pain relief with the injection was received only in 25% cases. They emphasized that the majority of the persistent pain could originate from another site other than pseudoarticulation site such as far out syndrome, foraminal stenosis, etc. In addition, they also pointed out that the LBA and radicular pain could also arise from L4 nerve compression because of overgrown L5 TP. They advocated additional decompression of L4 nerve root while bisecting the overgrown transverse process of L5.
Bertolotti’s syndrome with LBA may pose a great diagnostic dilemma to a clinician. The origin of pain is multifactorial. A diagnostic search for pain points should be done using an array of investigations viz. x-ray, MRI; CT scan, SPECT and bone scan. Initial treatment starts from conservative management just as with LBA with no BS. Along with pain medications, physiotherapy should be employed. In refractory cases, diagnostic injection of steroid and anesthetic agent can be given. If the pain relief is partial and shortlived, surgical means in form of resection or posterolateral fusion may be considered. Resection fairs better only in cases where facet joints are not so degenerated, while fusion surgery appears to be a worthwhile approach if advanced facet joint degeneration, spondylolysis, and spondylolisthesis are present at transitional vertebral level. A need of individualization of treatment strategy is of paramount importance. Moreover, further studies of higher evidence with large sample size are needed to delineate a definite management strategy for this potentially ambiguous area.