A Prospective, Double-blind, Randomised Controlled Trial of the Angiotensin Converting Enzyme Inhibitor Ramipril In Asymptomatic Aortic Stenosis (RIAS trial): Trial Protocol

Sacha Bull¹, Margaret Loudon¹, Jane M. Francis¹, Jubin.Joseph¹, Stephen Gerry², Theodoros D Karamitsos¹, Bernard D Prendergast³, Adrian P Banning³, Stefan Neubauer¹ and Saul G Myerson^1,3*

¹University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, UK, E-mail: saul.myerson@cardiov.ox.ac.uk

²Centre for Statistics in Medicine, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Oxford,OX3 7LD, UK, E-mail: saul.myerson@cardiov.ox.ac.uk

³Department of Cardiology, Oxford Heart Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK, E-mail: saul.myerson@cardiov.ox.ac.uk

^*Corresponding Author: Saul G Myerson, OCMR, Level 0, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK, Tel: 0044 1865222770, Fax: 0044 1865 740479 Email: