A Fourteen-Day Observation and Pharmacokinetic Evaluation after a Massive Intravenous Infusion of Hemoglobin-Vesicles (Artificial Oxygen Carriers) in Cynomolgus Monkeys

Kazuaki Taguchi¹, Hiroshi Watanabe^1,2, Hiromi Sakai³, Hirohisa Horinouchi⁴, Koichi Kobayashi⁴, Toru Maruyama^1,2 and Masaki Otagiri^1,5,6*

¹Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan

²Center for Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan

³Waseda Bioscience Research Institute in Singapore, Japan

⁴Department of Surgery, School of Medicine, Keio University, Japan

⁵Faculty of Pharmaceutical Sciences, Sojo University, Japan

⁶DDS Research Institute, Sojo University, Japan

^*Corresponding Author: Masaki Otagiri, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Kumamoto 862-0082, Japan, Tel: +81-96-326- 3887, Fax: +81-96-326-3887 Email: