Journal of Glycomics & Lipidomics
Open Access
ISSN: 2153-0637
ISSN: 2153-0637
Yury Miller, PhD
Associate Professor, Medicine
University of California, San Diego La Jolla, CA, USA
My laboratory studies inflammatory mechanisms involved in the development of atherosclerosis. Oxidized lipoproteins profoundly change the function of macrophages in atherosclerotic lesions. We study the role of 12/15-lipoxygenase and Toll-like receptors in the macrophage inflammatory responses. The hypothesis being tested is that 12/15LO-mediated modification of LDL produces ligands that activate TLR4 and other cellular receptors.
My laboratory studies inflammatory mechanisms involved in the development of atherosclerosis. Oxidized lipoproteins profoundly change the function of macrophages in atherosclerotic lesions. We study the role of 12/15-lipoxygenase and Toll-like receptors in the macrophage inflammatory responses. The hypothesis being tested is that 12/15LO-mediated modification of LDL produces ligands that activate TLR4 and other cellular receptors.