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Chief of Department of Hematology/Oncology, Clinical Assistant Professor Stanford University
Dr. Minggui Pan is the chief of Department of Hematology/Oncology at Kaiser Permanente Medical Center, Santa Clara, CA, and staff attending oncologist at Veterans Healthcare System, Palo Alto, CA, and Clinical Assistant Professor (affiliated) of Division of Oncology, Stanford University. His research has focused on elucidating the role of NFAT pathway in immune response, bone homeostasis and tumor immunobiology as well as the role of Brg1 gene in development and cancer. He has shown that CD28 plays part of its co-stimulatory role by increasing nuclear retention of NFATc1 in T cells. He has also found that NFATc1 regulates osteoblasts and a slight nuclear expression can cause osteopetrosis.
My research interest is focused on tumor immunobiology and developmental biology, specifically, how calcineurin-NFAT pathway regulates immune response, tumor surveillance, bone homeostasis, and cell growth and differentiation, and how the chromatin remodeling gene Brg1 regulates cell differentiation during development.