Enas S Kandil
Department of Anesthesiology and Pain Management
University of Texas Southwestern Medical Center, USA
My clinical training is in Anesthesiology and Pain Management at Case Western Reserve University, and the Cleveland Clinic. My early postgraduate career was focused on building my clinical pain management practice, given that my visa status at that time did now allow for any dedicated research time. Nevertheless, even during the years of my career that were dedicated to clinical practice, I remained intensely interested in the effects of opioids both in the OR, and in the outpatient setting. One of the initial questions that I asked was focused on reversing the effect of opioids used in the OR on prolongation of postoperative recovery. I was able to secure an investigator initiated pharmaceutical grant to conduct a small randomized-controlled clinical trial, which I have now completed (manuscript in preparation), where I demonstrated that operative opioid use was associated with a marked prolongation of postoperative recovery, and that the use of wake promoting agents such as Nuvigil is safe in the perioperative setting. Plans for subsequent studies are currently underway to examine the effects of larger doses of Nuvigil on reversing the effects of opioids in the perioperative period. Following completion of my clinical commitments in the VA as mandated by my visa status, I immediately enrolled in an NIH funded KL2 scholarship program at UT Southwestern Medical Center in the Department of Clinical Science and graduated in November 2015 with a master’s degree in clinical science (MSC). My research interests continued to focus on opioid safety and dependence. I currently have several ongoing clinical projects assessing and addressing prescription drug abuse in our Dallas area. Moreover, I am conducting a clinical trial to examine the opioid-sparing effect of lidocaine infusion in chronic pain patients. Although I did not have any formal training in bench research, I spent a year during my clinical training in a basic science laboratory where I studied the effect of NSAIDs on mitochondrial metabolism. More recently, I have started collaborations with several basic scientists at UT Southwestern to develop pain testing animal models.
Anesthesiology and Pain Management