+44 7868 792050
Department of Pharmaceutical Sciences
Northeast Ohio Medical University, USA
Deepak Bhatia, Ph.D. is an Assistant professor in the department of pharmaceutical sciences at Northeast Ohio Medical University and an adjunct professor in the School of Biomedical Sciences at Kent State University. Dr. Bhatia received his M.S. and Ph.D. in pharmaceutical and pharmacological sciences from West Virginia University followed by post-doctoral fellowship from City of Hope in the department of stem cells and leukemia research. During his Ph.D. he received fellowship form National Institute of Occupational Safety and Health (NIOSH). His current research is in the area of DNA damage signaling and chemoprevention. He serves as an ad-hoc reviewer for many journals and as editorial board member of international journal of pharmaceutical engineering. Dr. Bhatia also serves as an onsite evaluator for Higher Learning Commission.
The broad focus of my research is to investigate genetics and epigenetics changes in human lung cancer in response to genotoxic stress. Occupational exposure to mammalian cells elicit a variety of stress-related signals that lead to the altered expression of multiple genes involved in cell-cycle control, programmed cell death, and in some case DNA repair. Interestingly, key growth-control genes, such as the tumor suppressors p53 and RB and transcription factors such as Egr-1, Nf-kB, play central roles in some of these signaling pathways, and perturbations in their function in many human tumor cells have important implications in carcinogenesis. More interestingly, micro RNAs are also suggested to be involved in the regulating these genes that may act as oncogenic or tumor suppressor gene. Therefore, we aim to understand their function upon stress and ultimately use such genes and gene products as molecular genetic tools to employ novel "gene therapy" for the treatment of malignancies notably lung cancer. •Genetic and epigenetic changes in lung cancer upon genotoxic stress – microRNA regulation, cell cycle check points, histone methylation
•Chemo-preventive mechanism of dietary agents
•Free Radical Biology - Role of reactive oxygen and nitrogen species in cancer •Drug Delivery- functionalized nanoparticles and liposomes drug carriers for siRNA and miRNAs