Journal of Clinical Toxicology
Open Access

David R Wallace

Biography

Dr. Wallace received his Bachelor of Science degree from Western Michigan University in 1983 in Biomedical Sciences. His graduate work was completed at the University of Florida where he received his Doctoral degree in 1991 in Pharmaceutical Sciences. His first postdoctoral fellowship was at the University of Colorado (1990-92). Dr. Wallace joined the Oklahoma State University in 1996 after a 4 year fellowship at the University of Kentucky. Since his arrival, Dr. Wallace has been actively involved in teaching 2nd year medical students as well as graduate students in the Biomedical Science Program and the Forensic Science Program. Dr. Wallace has been extensively trained in basic pharmacological, neurochemical and neurotoxicological methods such as radioligand binding, neurotransmitter uptake/release and intracellular assays. The major foci and interests of the Wallace Laboratory are the mechanisms underlying neurotoxicity in the Central Nervous System (CNS) with a primary focus on environmental toxin and their effects on the dopaminergic neurotransmitter system.

Research Interest

My laboratory has 3 major projects currently underway. Project 1 examines the interaction between gp120/Tat (HIV proteins associated with neurotoxicity), estrogen, and cocaine in female rats. Ultimately, the goal of this research is to provide insight into gender-related differences in AIDS-related central nervous system disorders leading to potential gender-specific treatment strategies for HIV and cocaine addiction.  Project 2 examines the effects of low-level heavy metal exposure on the dopaminergic function in cell culture and whole animal. These studies have implications in forensic analysis and determining the potential cause of CNS damage.  Of major concern is that low-level exposure may also lead to the development of particular diseases of the CNS such as Autism Spectrum Disorders (ASD).  Project 3 investigates the use of naturally occurring compounds as centrally acting agents. One series of studies has been examining the effects of Native American plants indigenous to Oklahoma and their potential analgesic effects. A second series is investigating the estrogenic effects of flavonoids found in soy and flaxseed.