Professor and Director, Indiana Clinical and Translational Sciences Institute
Indiana University Medical Center, USA
I have lead a successful basic and clinical research programs in the areas clinical neuroscience and stress related disorders, funded by the NIH since 1989. The basic work focuses on the role of neurotransmitter and limbic pathway abnormalities that could lead to stress and psychiatric disorders and has more recently extended these studies to the discovery of new treatments. I also directed the Clinical Neuroscience Research Center (NCRC) at Indiana University School of Medicine from 1997 to 2007. Our group at the NCRC has conducted studies in healthy and disease populations, utilizing physiology and brain imaging methods. I hold several Investigational New Drug applications and discovery patents, and conducted many pharmacokinetic, pharmacogenetics, phase I and phase II studies of novel compounds in the treatment of schizophrenia, anxiety, and mood disorders. I have published over 140 original scientific papers in leading basic and clinical journals. A number of grants from the National Institutes of Health, private foundations, and commercial collaborations have supported my research.
Neuroscience and stress related disorders, Stress and psychiatric disorders