Journal of Hepatology and Gastrointestinal disorders
Open Access
ISSN: 2475-3181
ISSN: 2475-3181
Department of Plant Development, King Mongkut's University of Technology, Thon Buri, Thailand
Research Article
Sequence Variability of Hepatitis B Virus (HBV) Surface Antigen Gene (S Gene) among the Non-Responders of Antiviral Therapy
Author(s): Naveed Alam*, Zubaida Daudzai and Werasak Surareungchai
Prolonged administration of antiviral therapy for chronic hepatitis B may result in the development of hepatitis B
viral mutants. To gain insight into the mechanism involved in the sequence variability of Hepatitis B Virus (HBV)
surface antigen gene (S gene) among responders and non-responders to antiviral therapy, baseline characteristics of
the patients and sequences within the S region were investigated in pre-treatment serum samples of responders and
post-treatment serum samples of non-responders. The data was collected from 15 individuals with chronic hepatitis B
from Khyber Pakhtunkhwa (KPK) province, Pakistan. The antiviral response was independent of viral genotypes, and
nonresponse to antiviral therapy was associated with a complex variability of the viral mutants. The sequence analysis
of the S gene among responders and non-responders patients of pre and.. View More»
DOI:
10.35248/2475-3181.22.8.211