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Journal of Hepatology and Gastrointestinal disorders

Journal of Hepatology and Gastrointestinal disorders
Open Access

ISSN: 2475-3181

+44-20-4587-4809

Werasak Surareungchai

Department of Nanoscience and Nanotechnology, King Mongkut's University of Technology, Thon Buri, Thailand

Publications
  • Research Article   
    Sequence Variability of Hepatitis B Virus (HBV) Surface Antigen Gene (S Gene) among the Non-Responders of Antiviral Therapy
    Author(s): Naveed Alam*, Zubaida Daudzai and Werasak Surareungchai

    Prolonged administration of antiviral therapy for chronic hepatitis B may result in the development of hepatitis B viral mutants. To gain insight into the mechanism involved in the sequence variability of Hepatitis B Virus (HBV) surface antigen gene (S gene) among responders and non-responders to antiviral therapy, baseline characteristics of the patients and sequences within the S region were investigated in pre-treatment serum samples of responders and post-treatment serum samples of non-responders. The data was collected from 15 individuals with chronic hepatitis B from Khyber Pakhtunkhwa (KPK) province, Pakistan. The antiviral response was independent of viral genotypes, and nonresponse to antiviral therapy was associated with a complex variability of the viral mutants. The sequence analysis of the S gene among responders and non-responders patients of pre and.. View More»
    DOI: 10.35248/2475-3181.22.8.211

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