Journal of Clinical Toxicology
Open Access

Department of Biomolecular Sciences Division of Pharmacology, Mississippi, USA

Publications

• Review   
  Could Concurrent Use of Herbal Medicinal Products and Prescription Drugs Raise Older Adults Risk of Vascular Dementia?
  Author(s): Samantha Bodine, Logan Sneed and Zia Shariat-Madar*
  
  While the role of chemical insults or the buildup of chemical insults in cardiovascular pathogenesis continuously draws attention, the potential interference of a variety of currently used or investigational drugs on the ability of endothelial cells (ECs) which are responsible for providing a unique surface to allow the cellular elements of blood to flow without adhering to the vessel lining has been much less appreciated in drug discovery research. Activated ECs are more sensitive to long-term, continuous drug exposure than normal cells. Prolonged activation of ECs predisposes the blood vessel wall to vasoconstriction, leukocyte adherence, platelet activation, thrombosis, impaired coagulation, vascular inflammation, pro-oxidation, and atherosclerosis. The studies of hypercholesterolemia, homocystinemia, hyperglycemia, hypertension, smoking, inflammation, aging, d.. View More»
  DOI: 10.35248/2161-0495.20.10.439

  Abstract HTML PDF