Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Research Institute of Pharmaceutical Sciences, Mississippi, USA
Dr. Logan Sneed currently working in the Division of Pharmacology, University of Mississippi, Mississippi, the USA in the department of Biomolecular Sciences his publications are Could Concurrent Use of Herbal Medicinal Products and Prescription Drugs Raise Older Adults Risk of Vascular Dementia?
Review
Could Concurrent Use of Herbal Medicinal Products and Prescription Drugs Raise Older Adults Risk of Vascular Dementia?
Author(s): Samantha Bodine, Logan Sneed and Zia Shariat-Madar*
While the role of chemical insults or the buildup of chemical insults in cardiovascular pathogenesis continuously
draws attention, the potential interference of a variety of currently used or investigational drugs on the ability of
endothelial cells (ECs) which are responsible for providing a unique surface to allow the cellular elements of blood to
flow without adhering to the vessel lining has been much less appreciated in drug discovery research. Activated ECs
are more sensitive to long-term, continuous drug exposure than normal cells. Prolonged activation of ECs predisposes
the blood vessel wall to vasoconstriction, leukocyte adherence, platelet activation, thrombosis, impaired coagulation,
vascular inflammation, pro-oxidation, and atherosclerosis. The studies of hypercholesterolemia, homocystinemia,
hyperglycemia, hypertension, smoking, inflammation, aging, d.. View More»
DOI:
10.35248/2161-0495.20.10.439