Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Department of Organ Transplantation, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Research Article
Dexmedetomidine's Role in Modulating Postoperative Delirium Incidence and Pro-Inflammatory Cytokine Levels Interleukin-1 Beta (IL-1?), Interleukin-6 (IL-6) and Tumor Necrosis Factor-? (TNF-?) in Geriatric Thoracolumbar Compression Fracture Surgery Patients
Author(s): Caimin Ye, Jian Shen, Chengcheng Zhang, Zhibin Xu and Cuiyun Hu*
Objective: Evaluating dexmedetomidine's effectiveness in mitigating Postoperative Delirium (POD) and modulating
pro-inflammatory markers in elderly patients following thoracolumbar compression fracture surgery.
Methods: This randomized, double-blind, placebo-controlled study was conducted from October 2022 to January
2023 at the Anting hospital in Jiading district, Shanghai. It involved patients aged 65 and above undergoing
thoracolumbar compression fracture surgery. Participants were randomized into two groups; the Dexmedetomidine
(DEX) group, receiving 0.5 μg/kg/hour of diazepam and the Normal Saline (NS) group. Delirium incidence
was assessed on the 1st, 2nd and 3rd days post-surgery using the Confusion Assessment Method (CAM). Levels of
Interleukin-1 Beta (IL-1β), Interleukin-6 (IL.. View More»
DOI:
10.35248/2155-6148.24.15.1131