Drug Designing: Open Access

Drug Designing: Open Access
Open Access

ISSN: 2169-0138

+44 1223 790975

Z Shaikh

Department of Pharmacy, Humera Khan College of Pharmacy, Mumbai-400102, Maharashtra, India

  • Research   
    Repurposing Antimicrobial and Antifungal Agents as Potential BRAF Inhibitors
    Author(s): Manvi Kalia*, L Parmar, S Pathak, P Patwa, Z Shaikh and O Ghadge

    Objectives: To identify and select some of the existing molecules, with different therapeutic indications, as potential B-RAF inhibitors from literature. To explore and identify the appropriate B-RAF enzyme from the Protein Data Bank to carry out the molecular docking study on the selected molecules. To carry out the molecular docking studies on the selected molecules using molecular docking software AutoDock 4.2.2. Methods: Molecular docking studies were conducted using AutoDock 4.2.2 version software. Antimicrobial agents [pyrazine-2-carboxylic acid derivatives (D1-D10)] and antifungal agents [albendazole derivatives (A1-A22)] were repurposed as BRAF inhibitors. Results: Amongst the pyrazine-2-carboxylic derivatives compound D3 showed good results while amongst albendazole derivatives compound A12 showed promisin.. View More»
    DOI: 10.35248/2169-0138.22.11.205

    Abstract HTML PDF