Journal of Developing Drugs
Open Access
ISSN: 2329-6631
ISSN: 2329-6631
Department of Food Science, Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung, Taiwan
Research Article
Effects of a Food-Derived GLP-1 Formula on Endogenous GLP-1 Secretion and Appetite Responses: A Randomized Double-Blind Crossover Study
Author(s): Yung-Kai Lin, Shu-Ting Chan, Tony-T. Wu, Yung-Hsiang Lin, Lucas Chang and Chi-Fu Chiang*
Obesity and metabolic disorders are increasing worldwide and are closely associated with impaired glucose metabolism and appetite dysregulation. Glucagon-Like Peptide-1 (GLP-1) is an important incretin hormone involved in insulin secretion and satiety control. Food-derived approaches that enhance endogenous GLP-1 secretion may provide a practical strategy for metabolic health management. To evaluate the effects of a food-derived GLP-1 formula on GLP-1 secretion, insulin responses and appetite regulation in adults with elevated body fat levels. Fifteen participants were enrolled in a randomized crossover clinical trial. Subjects consumed either a food-derived GLP-1 formula containing Bifidobacterium breve, rocket apple extract powder and probio-kombu black tea powder or placebo. Following overnight fasting, blood samples and appetite assessments were collected over 240 min. The food-de.. View More»