Current Synthetic and Systems Biology
Open Access
ISSN: 2332-0737
ISSN: 2332-0737
Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung, Taiwan
Research Article
Oral supplementation of tripeptides (MAXI collagen) rapidly enhances collagen in human skin within 7 days: a double-blind, placebo-controlled study
Author(s): Tzu-Fang Hsu, Hsiu-Yu Sung, Ming-Chen Yeh, Yung-Kai Lin, Yung-Hsiang Lin, Shunji Hattori, Shu-Ting Chan, Yi-Wen Mao and Chi-Fu Chiang*
Tripeptides are recognized for their high bioavailability and their potential to improve skin structure, hydration and barrier function. This study evaluated the efficacy of MAXI collagen, a tripeptide-based formulation, through combined in vitro and clinical assessments. In cell models, MAXI collagen enhanced collagen production in CCD 966SK fibroblasts, suppressed melanogenesis-related gene expression (TYR, TYRP1, MITF) in A375 melanoma cells and increased SMPD1 along with key anti-aging and antioxidant markers (SIRT1, NADSYN, SOD3, Parkin) in HPEK keratinocytes, indicating broad skin-enhancing activity across multiple pathways. To validate these effects in vivo, a randomized, double-blind, placebo-controlled clinical trial was conducted in 75 adult participants aged 35-65 years. Participants were assigned to MAXI collagen, normal collagen, or placebo (n=25 per group) and consumed o.. View More»
DOI:
10.35248/2332-0737.25.13.122