Journal of Clinical & Experimental Dermatology Research

Journal of Clinical & Experimental Dermatology Research
Open Access

ISSN: 2155-9554

+44 20 3868 9735

Yu Zhang

Department of Dermatovenereology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518107, China

  • Research Article   
    Association between the MTHFR 677C/T Polymorphism and Susceptibility to Psoriasis: An Updated Meta-Analysis
    Author(s): Junhua Qi, Yu Zhang, Lvya Zhang and Gang Nie*

    The correlation between psoriasis and Methylenetetrahydrofolate Reductase (MTHFR) 677C/T polymorphism has been examined in a number of studies. However, the findings remain ambiguous. The present meta-analysis was conducted to comprehensively evaluate this issue. Eligible studies were searched in EMBASE, PubMed, Web of Science, Wan Fang Database, and Chinese National Knowledge Infrastructure (CNKI) up to December 31, 2021. Pooled Odds Ratios (ORs) with 95% Confidence Intervals (CIs) were calculated to estimate the effects of the MTHFR 677C/T polymorphism on psoriasis risk in different genetic models. Eleven relevant case-control studies were included in our meta-analysis, involving 2010 psoriasis cases and 1881 healthy controls. Pooled analysis suggested that the MTHFR 677C/T polymorphism was associated with increased psoriasis risk in the .. Read More»
    DOI: 10.35841/2155-9554.23.14.624

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