ISSN: 2471-9315
Department of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A and F University Hangzhou, Hangzhou, China
Review Article
New Insights into Porcine Endogenous Retrovirus (PERV)
Author(s): Dong Niu*, Tao Wang, Yu Liu and Yifan Niu
Xenotransplantation with porcine organs has been recognized as a promising solution to alleviate the shortage of
organs for human transplantation. Porcine Endogenous Retrovirus (PERV), whose proviral DNAs are buried in the
genome of all pig breeds, is a main microbiological risk for xenotransplantation. Over the last decades, some advances
on PERVs’ study have been achieved. Here we reviewed the current progress of PERVs including the classification,
molecular structure, regulation, function in immune system and potential risk in xenotransplantation. We also
discussed the problem of insufficient research on PERVs as well as the questions need to be answered in the future
work... View More»
DOI:
10.35284/2471-9315.23.9.247