Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

+44 1478 350008

Yifan Lv

Institute of Psychiatry and Neuroscience, Xin Xiang Medical University, Xinxiang, China

  • Research Article   
    Atypical Antipsychotic Olanzapine Induces Obese Via an Apoptotic Feedback Pathway
    Author(s): Yifan Lv, Shouqing Liu, Jia Tong, Qianqian Zhang, Zhongjian Zhang, Shiyong Peng*, Shihong Li, Ni Yang, Weiyong Li* and Wenqiang Li

    Olanzapine, a widely used antipsychotic, causes significant iatrogenic side effects of obese leading to non-compliance of antipsychotics in schizophrenia patients. However, the mechanism of olanzapine creating obese of metabolic disorders has remained elusive till now. Adipocyte proliferation was believed as general reasons for obesity-related diseases, convinced from our olanzapine-induced obese rat model. Our results demonstrated adipocyte proliferation through significantly elevating P-PI3K and P-AKT cascades in chronic treatment of olanzapine. Interestingly, significant activations of apoptosis through Klotho-Egr-1-MnSOD pathway were also observed in the obese rat model. We hypothesized that the activation of the apoptotic pathway could elicit a feedback response in adipocyte proliferation after olanzapine chronic treatments. Our results demonstrated that olan.. View More»
    DOI: 10.35248/2161-0495.20.10.453

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