Journal of Clinical Toxicology
Open Access

Section on Developmental Genetics, PDEGEN, NICHD, Bethesda, USA

Biography

Dr. Wenqiang Li currently working in Section on Developmental Genetics, PDEGEN, NICHD, Bethesda, USA his publications are A typical Antipsychotic Olanzapine Induces Obese Via an Apoptotic Feedback Pathway

Publications

• Research Article   
  Atypical Antipsychotic Olanzapine Induces Obese Via an Apoptotic Feedback Pathway
  Author(s): Yifan Lv, Shouqing Liu, Jia Tong, Qianqian Zhang, Zhongjian Zhang, Shiyong Peng*, Shihong Li, Ni Yang, Weiyong Li* and Wenqiang Li
  
  Olanzapine, a widely used antipsychotic, causes significant iatrogenic side effects of obese leading to non-compliance of antipsychotics in schizophrenia patients. However, the mechanism of olanzapine creating obese of metabolic disorders has remained elusive till now. Adipocyte proliferation was believed as general reasons for obesity-related diseases, convinced from our olanzapine-induced obese rat model. Our results demonstrated adipocyte proliferation through significantly elevating P-PI3K and P-AKT cascades in chronic treatment of olanzapine. Interestingly, significant activations of apoptosis through Klotho-Egr-1-MnSOD pathway were also observed in the obese rat model. We hypothesized that the activation of the apoptotic pathway could elicit a feedback response in adipocyte proliferation after olanzapine chronic treatments. Our results demonstrated that olan.. View More»
  DOI: 10.35248/2161-0495.20.10.453

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