International Journal of Physical Medicine & Rehabilitation
Open Access
ISSN: 2329-9096
ISSN: 2329-9096
Departments of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, USA
Research Article
Activated Frozen Mesenchymal Stem Cells in Humanized Mice after Induction of Acute Liver Injury through Alcohol Binging
Author(s): Juan Carlos Hernandez, Yicheng Aiden Zhu, Sean P. Martin, Nathan Kohrman, Da-Wei Yeh, Joel Marh, Karina Zaragoza, Hye Yeon Choi, Julia Kim, Shefali Chopra, Li Ding, Matthew Thornton, Brendan Grubbs, Leonard Makowka, Linda Sher* and Keigo Machida*
Background: After acute injury there are a variety both modifiable and unknown factors that contribute to the liver’s ability to recover. This group previously demonstrated that treatment with activated umbilical cord Mesenchymal Stem Cells (MSCs) increased the survival of mice with humanized livers who developed alcoholinduced liver injury.
Objective: This study’s primary objective was to evaluate the safety and efficacy of various doses of frozen-thawed activated MSCs compared to placebo in the treatment of acute alcohol-induced liver injury in humanized mouse livers. Secondary objectives included evaluating hepatic chemistries, biomarkers and pathology at various doses.
Methods: Sixty-two humanized mice that were fed high fat diets and alcohol binge drinking for 24 days were randomized to receive 1 m.. View More»
DOI:
10.35248/2329-9096.24.12.723