Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Department of Rehabilitation Medicine, Nanfang Hospital, The First Clinical Medical College of Nanfang Medical University, Guangzhou, China
Research Article
The Oncogenic Role of ?-Aminobutyrate Aminotransferase in Human Tumor: A Pan-Cancer Analysis
Author(s): Xinyu Wang, Yi Jie, Hui Yu and Anqin Dong*
Emerging evidence supports the correlation between γ-aminobutyrate aminotransferase (ABAT) and tumors, but few research groups used pan-cancer analysis to verify it previously. Therefore, this study used The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) to obtain information about the correlations between ABAT and tumor development, and to explore its potential effectiveness for genetic alterations in tumor prognosis. The reduced expression level of ABAT in a majority of tumors is significantly associated with the poor prognosis. The genetic alteration of ABAT seems linked to the favorable prognosis of Uterine Corpus Endometrial Carcinoma (UCEC). Immune infiltration analysis showed a significantly positive correlation between ABAT and cancer-associated fibroblasts in the majority of tumors, but a highly negative correlation with Kidney Renal.. View More»
DOI:
10.35248/2167-7700.23.11.183