Pancreatic Disorders & Therapy

Pancreatic Disorders & Therapy
Open Access

ISSN: 2165-7092

+44 1478 350008

Xianzhong Ding

Loyola University Medical Center, Loyola University Chicago Stritch School of Medicine, Maywood, USA

  • Abstract   
    Adjuvant Systemic Therapy for Intestinal Type Invasive IPMNs: A Case Series and Brief Literature Review
    Author(s): Brian E. Johnson*, Daniel S. Peiffer, Asha Dhanarajan, Ami Badami, Xianzhong Ding and Kenneth Micetich

    Intraductal Papillary Mucinous Neoplasms (IPMNs) are epithelial neoplasms that can progress to invasive pancreatic malignancies. While the Sendai guidelines can assist us regarding which IPMNs are likely to be invasive and therefore need resection, there are limited data about management after resection. The adjuvant therapy for resected Invasive IPMNs (I-IPMNs) is currently based off of limited retrospective analyses and expert opinion extrapolating primarily from pancreatic exocrine regimens. The heterogeneity in both pathology and treatment response as seen in a recent systematic review suggests that we should consider delineating between the broad categories of intestinal/colloid type and pancreatobiliary/tubular type I-IPMNs to guide adjuvant systemic therapy similar to what is done with ampullary malignancies. Without prospective studies to guide our treatment decisions, we perf.. View More»

    Abstract PDF