International Journal of Physical Medicine & Rehabilitation
Open Access
ISSN: 2329-9096
ISSN: 2329-9096
Department of Urology, Jen-Ai Hospital, Taichung City, Taiwan
Original Research Article
Gigantol, A Biphenyl Phenolic Compound of Medicinal Orchids, against Amyloid β Aggravation of SH-SY5Y Neuroblastoma Cell Injury Induced by Advanced Glycation End Products
Author(s): Mei Chou Lai, Wayne Young Liu, Shorong-Shii Liou and I-Min Liu*
Background: Advanced Glycation End products (AGEs) has been identified as a significant source of neurotoxicity in Alzheimer's Disease (AD). There is growing evidence confirming that many medicinal plants and natural compounds can potentially lessen the progression of neurodegenerative disorders or avert the onset of neurodegeneration, thus attracting much attention. Gigantol, a biphenyl phenolic compound isolated from orchids of the genus Dendrobium, has been reported to halt high glucose-induced renal dysfunction. Based on these data, gigantol has been proposed as a preventive treatment against cells from hyperglycemia or glycation-associated damages; however, there is no comprehensible evidence. AGEs induced damage in SH-SY5Y neuroblastoma cells was used to clarify the beneficial effects of gigantol on AD.
Methods and findings: Before.. View More»
DOI:
10.35248/2329-9096.22.S16.002