Journal of Pharmaceutical Care & Health Systems
Open Access

Department of Pharmacy, MCPHS-Boston University, Boston, USA

Publications

• Research Article   
  Novel Solid Lipid Nanoparticles Formulation of Ion Paired Cefepime for Enhanced Oral Absorption
  Author(s): Wala’a AlBenayan, Basel Karzoun, Eman Atef* and Christianne Rizkalla
  
  We report a successful formulation of (CEF) ion paired Solid Lipid Nanoparticle (SLN) with a demonstrated improvement of the intestinal membrane permeability up to 41 folds. Cefepime is a parentally administered fourthgeneration cephalosporin zwitterion. The class 3 BCS drug has high water solubility and low permeability, which result in low oral bioavailability. Our goal is to overcome the low oral bioavailability challenge using double techniques, a molecular alteration ion pairing, and a Nano carrier formulation approaches. The CEF ion pair was prepared by freeze-drying dispersions of an anionic lipid, Sodium Stearate (NaSA), with CEF. Then a combination of Precirol ATO ® 5 and Compritol 888 ATO ® lipids was used in preparing the SLNs using the microemulsion-ultrasonication technique. The enhanced drug permeability was confirmed using an ex vivo rat intestine in a.. View More»
  DOI: 10/35248/2376-0419.2022.237

  Abstract HTML PDF