Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
ISSN: 2165-8048
Robert H. Lurie Comprehensive Cancer Cente, Northwestern University, Chicago, IL, USA
Research Article
MRI Assessment of Associations between Brown Adipose Tissue and Cachexia in Murine Pancreatic Ductal Adenocarcinoma
Author(s): Yaqi Zhang, Su Hu, Junjie Shangguan, Liang Pan, Xin Zhou, Vahid Yaghmai, Yuri Velichko, Chunhong Hu, Jia Yang and Zhuoli Zhang*
Objective: As the major thermogenic tissue in body, the brown adipose tissue (BAT) was recently identified as an important factor to induce the rapid weight loss and malnutrition in malignancy. Current methods for detecting and quantifying brown adipose tissue (BAT) are in limited use. The aim of this study was to evaluate the changes of BAT tissue and its function in the development of pancreatic ductal adenocarcinoma (PDAC) by using magnetic resonance imaging (MRI).
Methods: Ten-week-old female C57BL/6 mice were inoculated orthotopically with Pan02 tumor cells. R2* maps and two-point Dixon MRI were performed weekly for evaluation of BAT function and volume, respectively. The T2- weighted MRI was applied weekly for monitoring tumor growth. Meanwhile, the body weight was measured daily as another indication of malnutrition. The UCP1.. View More»
DOI:
10.35248/2165-8048.19.9.301