Immunome Research
Open Access
ISSN: 1745-7580
+44-20-4587-4809
ISSN: 1745-7580
+44-20-4587-4809
Department of Bioinformatics, DETAGEN Genetics Diagnostic Center, Kayseri, Turkey
Research Article
Immunoinformatics Approach for Designing an Epitope-Based Peptide Vaccine against Treponema pallidum Outer Membrane Beta-Barrel Protein
Author(s): Mustafa Elhag*, Moaaz Mohammed Saadaldin, Abdelrahman Hamza Abdelmoneim, Taha Salah Taha, Fatima Abdelrahman and Mohammed A Hassan
Treponema pallidum is a gram negative bacteria and the main cause of syphilis which is classified as chronic inflammatory discompose antecedent transmitted sexually. Syphilis affects the central nervous system and the cardiovascular system, potentially leading to hearing or visual loss, aortic aneurism, stroke-like syndrome, dementia and paralysis. T. pallidum has the ability to stimulate adaptive immune and corresponding innate procedures in tissue and blood that might set the era for the HIV’s bidirectional transmission. This study expects a real epitope-based vaccine against β-Barrel outer membrane protein of Treponema pallidum designed by immunoinformatics approaches. The sequences were saved from NCBI and a number of prediction tests were undertaken to explore possible epitopes for B-cell, T-cell MHC class I and II. 3D structure of the most hopeful epitopes was illustr.. View More»
DOI:
10.35248/1745-7580.20.16.175