Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609


Sushant Kumar

Dr, Department of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai,Etawah, India

  • Research Article   
    Nanosized Model Drug Loaded Bio-Nano Suspension: It’s Development, Characterization and Evaluation
    Author(s): Sushant Kumar*, N.V. Satheesh Madhav and Swarnima Pandey

    The objective of this research was to develop the phenytoin loaded bionanosuspension by using the novel biopolymer from Juglans regia. The different ratio of phenytoin and biopolymer (1:0.8, 1:1,1:2,1:3,1:4,1:5,1:8) were taken for preparation of formulations PJ1-PJ7. The bionanosuspension were evaluated for spread ability test, pH% entrapment efficacy, bio nanoparticles size in bionanosuspension, zeta potential, stability study and in-vitro drug release study. The formulation PJ2 with 1:1 drug biopolymer ratio was found to be best stable bionanosuspension on the basis of above evaluation parameters. The best formulation PJ2 showed the significant satisfactory results for different evaluations with t 50% of 18.09 hours and t 80% of 29.77 hours with r2 value of 0.9970. The best formulation PJ2 showed up to 86.56% ± 3 drug release in 36 hours. The bionanosuspension was found to be.. View More»
    DOI: 10.35248/2157-7609.21.12.257

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