Journal of Glycobiology
Open Access
ISSN: 2168-958X
ISSN: 2168-958X
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, USA
Research Article
A High-level Over-Expression of N-and O-Glycan Glycosyltransferases in Pancreatic Tumors and Diabetic Neutrophils: An Unique Pathological Situation in Pancreatic Cancer and Diabetic Retinopathy
Author(s): Chandrasekaran EV*, Dhananjay DMarathe, Sriram Neelamegham, Joseph Y Lau and Khushi L Matta*
Diabetes is a widely existing disease in patients at risk of pancreatic cancer. It originates from pancreatic endocrine gland whereas pancreatic cancer develops from exocrine glands. Leukocyte cell surface glycans are involved in leukocyte-endothelial cell adherence and retinal endothelial cell death in diabetic retinopathy. A stimulation of hexosamine biosynthesis pathway occurs in diabetes and in pancreatic cancer controlled by oncogene KRAS variant. We examined 5 pancreatic non-tumor and 14 pancreatic tumor tissue specimens for quantitative changes in glycosyltransferse.. View More»