Journal of Physical Chemistry & Biophysics
Open Access
ISSN: 2161-0398
ISSN: 2161-0398
Department of Technological Industry and Energy, Thebes Technological University, Thebes, Luxor, Egypt
Research
A Simple and Efficient Multicomponent Synthesis of Novel Pyrazole, N-Aminopyridine and Pyrazolo[3,4-b]Pyridine Derivatives in Water
Author(s): Mervat Mohammed Abdelkhalik*, Abdulaziz Alnajjar, Solwan Maher Ibrahim, Mohammed Abdelmonem Raslan and Kamal Usef Sadek
The three-component reaction of enaminones, benzaldehyde and hydrazine-HCl or four-component reaction of
enaminones, benzaldehyde, hydrazine-HCl and ethyl cyanoacetate in water in the presence of catalytic amount of
ammonium acetate has been devised as a straightforward, sustainable approach for the synthesis of 1-H-pyrazole,
N-aminopyridine and pyrazol[3,4-b]pyridine derivatives. The key benefit of this approach is simple experimental
procedure associated with cost effective and environmentally friendly techniques... View More»
DOI:
10.35248/2161-0398.24.14.371