Journal of Cell Science & Therapy

Journal of Cell Science & Therapy
Open Access

ISSN: 2157-7013

Sijie Liu

Peking-Tsinghua Center for Life Sciences, National Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China

  • Mini Review   
    A Recently Discovered Essential Factor for DNA Homologous Recombination: RNA Polymerase III
    Author(s): Sijie Liu*, Xiaoqin Liu and Daochun Kong*

    End resection is a central step in DNA homologous recombination (HR) and the HR-mediated repair of DNA double-strand breaks (DSBs), which degrades 5’-end strands at DSBs by several kilo-bases and thus creates 3’-end single-strand DNA overhangs. A critical long-standing question is how the 3’-end strands are protected during end resection. Now, this question is answered. Liu et al. found that the protection of 3’-end strands is achieved by the formation of an RNA-DNA hybrid. RNA polymerase III is responsible for catalyzing the RNA strand in the hybrid. Thus, RNA polymerase III is an essential factor for HR, and the RNA-DNA hybrid is an essential HR intermediate... View More»
    DOI: 10.35248/2157-7013.21.12.302

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