Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu, China
Research
Differences in Gene Mutation Profiles of Colon Cancer Patients with or without a KRAS Mutation
Author(s): Shujian Chang*, Yudan Zhou, Ruirong Wu, Xiaosong Ge and Yong Pu
In order to compare the gene mutation profiles of patients with or without a KRAS mutation, the clinicopathological data of 858 patients and NGS test results of 1697 patients with colorectal cancer were used in this analysis. In 858 patients, only 2 out of 349 (0.5%) KRAS mutant patients had a BRAF mutation, while 25 out of 422 (5.9%) KRAS wild-type patients had a BRAF mutation (p<0.0001). The NGS results showed that in RAS mutant patients, genes with a high mutation rate mainly included APC, TP53, PIK3CA, Smad4, and Fbxw7, and in RAS wild-type patients, genes with a high mutation rate mainly included TP53, APC, LRP1B, MYC, and BRAF. The mutation rates of BRAF and EGFR in the RAS wild-ty.. View More»
DOI:
10.35248/IGOA.22.7.175