International Journal of Physical Medicine & Rehabilitation
Open Access
ISSN: 2329-9096
ISSN: 2329-9096
Department of Circulatory and Respiratory Advanced Medicine, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu City, Gifu 501-1194, Japan
Commentary
Prognosis of Heart Failure and Sympathetic Nerve Activity
Author(s): Shinya Minatoguchi*
The prognosis of heart failure is poor and plasma noradrenaline level is a good predictor of the survival rate of heart
failure patients. Sympathetic nerve activity is augmented in patients with heart failure as evidenced by a higher
noradrenaline release rate from the sympathetic nerve endings. Drugs for heart failure such as β-blockers,
angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, mineralocorticoid antagonists, ivabradine,
Angiotensin Receptor-Neprilysin Inhibitor (ARNI), and Sodium-Glucose Transport Protein 2 (SGLT2) inhibitors
have clinical evidences for improving prognosis of heart failure in large randomized-controlled clinical trials.
Interestingly, the same characteristics in common of these drugs is to reduce sympathetic nerve activity. In addition,
cardiac rehabilitation which causes a better prognosis of heart failure re.. View More»
DOI:
10.35248/2329-9096.22.10.628